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You will NOT find me on ‘SOCIAL MEDIA’
Overview 2025
Necrotizing Myopathy
Necrotizing myopathy can also be referred to as necrotizing autoimmune myopathy (NAM) or immune-mediated necrotizing myopathy (IMNM). The condition is characterized by signs of necrosis, or cell death, in the muscles, which causes weakness and fatigue.
As with other types of myositis, there is no known cause or cure for necrotizing myopathy.
Signs and Symptoms
Like other forms of myositis, patients with necrotizing myopathy may experience the following symptoms:
*I should add, that these, are what I have experienced, overcome re some ...SOME cannot be bypassed, or overcome.
1. Weakness in the muscles closest to the centre of the body, such as the forearms, thighs, hips, shoulders, neck, and back
2. Difficulty climbing stairs and standing up from a chair.
3. Difficulty lifting arms over the head.
4. Falling and difficulty getting up from a fall.
5. A general feeling of tiredness.
Disassociated From Polymyositis ?
Necrotizing myopathy is a newly defined form of idiopathic inflammatory myopathy, or myositis.
Patients with necrotizing myopathy have muscle biopsies that show much less inflammation in the muscle tissue than polymyositis patients, but they have
increased evidence of muscle cell death, or necrosis.
In the past, all patients with muscle weakness, elevated creatine kinase levels
(mine were over 11,00 rising to over 20,000 + ) in their blood, and other symptoms of myopathy, but who didn’t have skin involvement, were diagnosed with polymyositis. Now, it is recognized that some of these patients have unique findings on their muscle biopsies that distinguish them from those with polymyositis or other forms of myositis.
Categories of Necrotizing Myopathies
Researchers are also beginning to distinguish different categories of necrotizing myopathy that have different risk factors and different treatments. These distinctions are based on the presence of different autoantibodies in the patient’s blood and most likely indicate that these are different diseases.
Patients with SRP Autoantibodies
Anti-signal recognition particle (SRP) autoantibodies appear in the blood tests of many experiencing symptoms of necrotizing myopathy. Patients typically experience sudden and extreme muscle weakness and aches. Some may also have cardiac involvement.
Patients with HMGCR Autoantibodies
HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase) is a key enzyme in the production of cholesterol. Patients who have anti-HMGCR antibodies and use statin medications to control high cholesterol may unknowingly develop this type of statin-induced necrotizing myopathy.
All Other Patients
All other patients with necrotizing myopathy, who do not show SRP or HMGCR autoantibodies in their blood tests are considered by some experts to be included in a separate, third grouping of necrotizing myopathy.
I have some of the above AND
Neuralgia with the NECROSIS.. Myopathy broad spectrum.
You can stick needles into me and, I used to feel the SENSATION of the needle going in? NOW I feel NOTHING!
Muscles have become seriously problematic re wastage coupled with neuropathy = lower limbs etc 50% plus AND upper torso/limbs 40-50% nerve damage resulting in numbness of the regions affected.
Body temperature can and DOES drop to
HYPOTHERMIC -35C
Dermotomyositis !!! Buttocks left AND right.. plus around the waist area...
I have had SHINGLES.
CHRONIC FATIGUE is a total nightmare and interferes with my writing et though I do remarkably well given that as an issue.
Sjögren's syndrome MORE here throat remains affected by this. FACT. This is ongoing and NOT intermittent ! I suspect it may also be a reason directly or indirectly, for my sinus issues.
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